Interferon-alfa: um disruptor endócrino?

[Interferon-alpha: a endocrine disruptor?].

Adjuvant interferon alfa for melanoma.

The author poses the question “Why did these study results not lead to a global consensus about interferon treatment as standard of care?” The answer is quite simple: The E1684 adjuvant high-dose interferon (hdifn) trial, while initially positive, was later shown to be negative. Remarkably, in spite of a p value of 0.09, the principal investigator still interpreted the trial as positive 1. Canc...

Interferon Alfa-2b Therapy in Mucocutaneous Manifestations of Behçet’s Disease

Background: Viral infections such as Epstein-Barr virus and Herpes simplex virus may play a role in the pathogenesis of Behçet’s disease (BD). Interferons (INF) are natural defense mechanisms against viruses and inhibit their activities by enhancing major histocompatibility complex class I and cytokine expression. This study evaluated the efficacy of INF-α-2b on mucocutaneous lesions of BD. Met...

Interferon alfa-2a in recurrent metastatic hemangiopericytoma.

1. Webber BL, Parham DM, Drake LG, et al. Renal tumors in childhood. Pathol Ann Part 1992;1:191–232. 2. Murphy WM, Beckwith JB, Farrow GM. Tumors of the kidney, bladder and related urinary structures. In: Murphy WM, Beckwith JB, Farrow GM, editors. Atlas of tumor pathology, series 3, fascicle 11. Washington D.C.: Armed Forces Institute of Pathology, 1994. 3. Beckwith JB. Pediatric neoplastic di...

Lymphoblastoid interferon alfa treatment in chronic hepatitis

Interferon is becoming the standard treatment in adults for chronic hepatitis C. Twenty one children with histologically proved chronic hepatitis C (10 boys, range 2 5-13 years), who were otherwise healthy, were enrolled in a randomised controlled study to test their response to interferon alfa. Eleven children were treated with lymphoblastoid interferon alfa (3 million units/M2) for 12 months;...